Police say the crash happened around 10:25 p.m. Thursday on southbound US-1, near Canaveral Groves Boulevard in Cape Canaveral.
Search for hit and run driver that killed Melbourne man in a wheel chair
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Reports say that the man was struck by a driver in a 2013 to 2017 Buick Enclave of unknown color.
The vehicle is believed to have front-right damage and missing a right fog light molding.
The 47-year-old man from Melbourne died from his injuries sustained in the crash. Anyone with information on the crash is asked to call Florida Highway Patrol at 407-737-2200 or Crime Line at 800-423-TIPS (8477.)